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2017, Huang 2018)

After ingestion, folate from food is hydrolyzed in the gut, where it is converted first to tetrahydrofolate by the enzyme dihydrofolate reductase and then to the active form 5-MTHF, by the enzyme MTHFR

A 70 mg vial reconstituted with 3 mL of bacteriostatic water yields 10 units per injection and lasts one 30-day cycle

FOXO4-DRI has a rapidly expanding and high-impact published research base, with studies published across Nature, Nature Communications, Communications Biology, Aging, Frontiers in Bioengineering and Biotechnology, and PMC since its foundational description in 2017

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