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In a series of 2018 studies on rats, macaques, and humans, Dr

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They are commonly combined in research planning because they act on two different GH pathways, and GHRH-plus-secretagogue pairings have amplified GH pulses in human secretagogue studies

paper in Aesthetic Surgery Journal Open Forum (doi:10.1093/asjof/ojaf030) hypothesized that long-term GLP-1RA use may produce skin atrophy through a mechanism similar to glucocorticoid-induced thinning, citing the Nagae 2018 work and other in vitro evidence