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Muscle soreness, clinically referred to as Delayed Onset of Muscle Soreness or DOMS, is actually caused from inflammation

The reduction in markers of inflammatory vasculopathy observed in 4.2 / mice with or without spleen further corroborate the attractive therapeutic profile of mitapivat in HS and in other membranopathies such as stomatocytosis, where splenectomy is contraindicated due to a significantly increased thrombotic risk

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