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The compound's mechanism involves several physiological processes: Receptor Binding: Attaches to GHRH receptors on the pituitary gland Stimulation: Promotes endogenous GH production Feedback Regulation: Controlled by somatostatin for safety Gene Activation: Stimulates pituitary GH messenger RNA transcription A single sermorelin injection may increase GH levels for up to six hours, with repeated administrations maintaining elevated levels for up to two weeks

It is primarily investigated in preclinical settings

This depends on how you define the evidence

doi: 10.1016/0006-2952(84)90209-0

10.1016/J.BBRC.2018.08.171 13 BenagliaL.CardellicchioL.FilippiF.PaffoniA.VercelliniP.SomiglianaE.et al (2014)