Combating Oxidative Stress: Oxidative stress, caused by an imbalance between free radicals and antioxidants in the body, is a major contributor to premature aging
In the one available PET study in LLD, five older adults showed elevated TSPO in the sub-genual cingulate gyrus, along with hippocampal subfield atrophy and increased CRP levels, compared to controls [281]
Maintaining optimal levels of glutathione appears to be important for supporting cognitive function, especially as we age.* The normal process of aging is associated with a decrease in glutathione regulation, which can result in increased oxidative activity.* Less than optimum levels of glutathione are observed in individuals experiencing a decline in cognitive function.* Conversely, individuals living over 100 years tend to have higher glutathione reductase activity.* A common mistaken belief is that glutathione is not well absorbed when its taken orally, but significant data confirms it is efficiently absorbed across the intestinal epithelium by a specific uptake system.* Glutathione-SR from Thorne Research represents an important breakthrough in glutathione supplementation
The effects were modest, but the study suggested immune modulation might be part of the benefit
serious but rarer effects include pancreatitis, gallbladder disease, and diabetic retinopathy complications