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Both incorporate glucagon receptor agonism alongside GLP-1 activity, but retatrutide takes this further by adding a third target -- GIP receptor agonism -- making it the first triple-hormone receptor agonist in clinical development

Intraintestinal injection of a recombinant adenovirus constitutively expressing GLP-1 produces insulin-positive cells in the intestines, significantly increases serum insulin, reduces blood glucose levels, and improves glucose tolerance[104]

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In contrast, a higher intake of trans fats was strongly correlated with a reduced likelihood of healthy aging