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This process markedly reduces urinary carnitine loss and is essential for maintaining systemic free carnitine homeostasis and supporting fatty acid -oxidation in high-energy-demand tissues such as the heart and skeletal muscle [95]

This substance performs several important functions in the body

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Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]