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Based on affinity chemical proteomics, the chloroacetamide part of the RSL3 structure is essential for its activity

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Moreover, in our recent study we also demonstrated that repeated administration of the BSO + GBR 12909 to 16-day-old rats induced a significant reduction in the level of lipid peroxidation in the frontal cortex and hippocampus, indicating a weakening of the oxidative power of their cells and ultimately leading to changes in redox cell signaling in the frontal cortex and hippocampus (40)

Oxidatie stress as a common key event in developmental neurotoxicity