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P.YangL.ChenQ.ChenY.TengY.WangP.et al (2018)

A randomised controlled trial published in Clinical Infectious Diseases demonstrated that Thymosin Alpha-1 treatment in severe COVID-19 patients reduced 28-day mortality by 30% compared to standard care alone.17 While this was acute disease, not long COVID, it confirms the biological plausibility of the immune mechanism

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In summary, obesity results from multiple endocrine dysfunctions that inhibit the HPG axis, and weight loss surgery can mitigate pathological estrogen levels and relieve this inhibition