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Different receptor targets mean different downstream effects

Fasting is conventional (1-2 hours before and 20-30 minutes after the injection) because elevated plasma glucose blunts the GH pulse

Thai T-H, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y, Murphy A, Frendewey D, Valenzuela D, Kutok JL, Schmidt-Supprian M, Rajewsky N, Yancopoulos G, Rao A, Rajewsky K 2007 Regulation of the germinal center response by microRNA-155

Overexpressing ACMSD reduces the NAD + level by dissipating ACMS from the de novo NAD + synthesis into the side branch pathway for acetyl-CoA production, while inhibiting ACMSD elevates NAD + concentration

doi: 10.1016/S1097-2765(00)00051-4 69