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In the SURPASS-6 trial, TZP was compared to insulin Lispro three times daily in diabetic patients previously treated with a dose of insulin glargine, with or without metformin

Patients with contraindications - including personal or family history of medullary thyroid carcinoma or MEN 2 syndrome, pancreatitis history, severe GI or kidney disease, pregnancy, or breastfeeding - won't be approved

Gastrointestinal side effects, mostly with symptoms of transient fullness and nausea, are typical for the initiation of treatment

The notion that all GLP-1s are the same and interchangeable is not correct, Jason Brett, executive medical director for Novo Nordisk, said in a statement