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Repeated measures ANOVA indicated a significant treatment effect, F 3,24 =62.58

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Then the brains and serum were collected (see ESM Methods: Immunohistochemistry) for analysis of secondary outcomes (stroke volume, number of neurons positive for the neuronal nuclear marker [NeuN] and serum IGF-1 levels, see ESM Methods: Ischaemic stroke volume assessment and ESM Methods: ELISA immunoassays)

Rather than avoiding GLP-1 RA therapy, clinicians should maintain dermatologic awareness and monitor for new-onset skin disease, particularly during early treatment

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