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The nervous system precisely discharges acetylcholine from the terminals of the vagus nerve [236]
It is widely used clinically to treat drug-induced liver injury (DILI) by protecting hepatocyte membranes, exerting anti-inflammatory and immunomodulatory effects, and demonstrating corticosteroid-like actions that promote hepatocyte repair, enhance hepatic protein synthesis, prevent fibrosis, and strengthen anti-allergic and detoxification capacities
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Besides its presence in the brain, GHSR can also be found in the gastrointestinal tract, heart, lung, liver, kidney, pancreas, adipose tissue and immune cells
Protein post-translational modifications regulated by butyrate Acetylation Lysine acetylation (Kac), a critical post-translational modification, involves the covalent attachment of acetyl groups to lysine residues, dynamically controlling protein functions, cellular signaling, and epigenetic states
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