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Intestinal motility: GLP-1s can influence how quickly (or slowly) waste moves through the intestines, affecting bowel habits

Lancet 394:131138 Tuttle KR, Lakshmanan MC, Rayner B, Busch RS, Zimmermann AG, Woodward DB et al (2018) Dulaglutide versus insulin glargine in patients with type 2 diabetes and moderate-to-severe chronic kidney disease (AWARD-7): a multicentre, open-label, randomised trial

Nat Rev Mol Cell Biol 21(10):607632

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Answer: Growth hormone and IGF-1 output decline with age, deep-sleep windows that trigger natural growth hormone pulses shorten, and these shifts make fat harder to lose and muscle harder to keep, which is the gap this stack is designed to address