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However, there have been many successful cases demonstrating the critical role of nanomaterials: for example, natural ursolic acid-based carriers can deliver resveratrol in a targeted manner to repair renal injury (Nie et al., 2023)

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Thus, mTORC1 promotes the nuclear translocation of the cAMP response element-binding protein (CREB) which stimulates the transcription of the anti-apoptotic gene MCL-1 in the nucleus and the upregulation of the Bcl-2 family protein myeloid cell leukemia 1 (Mcl-1) [300]

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