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The presence of amino-isobutyric acid (Aib) at the N-terminal end potentially increases resistance to enzymatic breakdown

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the metabolism of carbohydrates, blood glucose, fats, and proteins

Similar to the story of GLP-1 drugs, the weight loss effects of targeting glucagon and GIP could have only been achieved with drugs that could chronically activate hormone receptors across the body, drugs with effects that are more potent and widespread in the body than the natural hormones that are secreted

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