Major guidelines recommend GLP-1RAs as first-line therapy in patients with T2D who have, or are at high risk for, atherosclerotic cardiovascular disease, chronic kidney disease (CKD), or obesity
These peptides can help manage conditions like leaky gut, IBS, and Crohns disease by improving mucosal integrity and reducing oxidative stress
The primary cause of glucotoxicity is insulin resistance, which arises from defective islet cell function and damage caused by reduced insulin mRNA expression, associated with diminished transcription or activity of transcription factors involved in insulin production (Mota et al., 2016)
LiveWell MOTS-c is intended strictly for laboratory research use only
Luciferase reporter assay Luciferase reporter assays were performed as described previously 82,123