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(2025) trial included both sexes

However, DIO mice switched from an obesity-promoting WD to an LD (regardless of treatment status) displayed several genera and phyla differences compared to obese and lean controls

Women who are pregnant, planning pregnancy, or breastfeeding should avoid the compound entirely due to unknown effects on fetal and infant development

The researchers concluded that AOD9604 displayed a very good safety and tolerability profile indistinguishable from placebo. Critically, zero serious adverse events were attributed to the peptide, and no participants withdrew due to treatment-related effects