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10.1111/cns.13791 96 StevenS.JurkK.KoppM.Kroller-SchonS.MikhedY.SchwierczekK.et al (2017)

Systems biology studies: assessing tissue or regional receptor expression and pathway signatures using agonist stimulation frameworks

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71.2 lbs on average) Retatrutide 9mg: 26.4% body weight reduction Tirzepatide/Zepbound (Phase 3 comparison, not head-to-head): ~20.9% Semaglutide/Wegovy (Phase 3 comparison, not head-to-head): ~14.9% Placebo: ~2.1% Note: These figures come from separate Phase 3 trials and are not direct head-to-head comparisons