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That said, "no serious toxicity in animal models" is not the same as "proven safe in humans long-term," and anyone with a personal or family history of cancer should treat the angiogenic mechanism above as a genuine reason to talk to a qualified clinician before starting

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Vegans boosted out of deficiency chewing a B12 supplement, but nothing in those who just swallowed it whole

Patients should never double up on doses or take extra medication to compensate for missed doses, as this increases the risk of adverse effects without providing additional therapeutic benefit