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Studies of acute GH exposure have shown increases in skeletal muscle mitochondrial oxidative capacity and upregulation of mitochondrial gene expression, indicating that upstream endocrine changes can meaningfully influence how peripheral tissues process available fuel

Sommer A, Twig G

Lets see how: In the foetus: heart disease, and intrauterine growth restriction Newborns: poor feeding, microcephaly (smaller than usual head size), and encephalopathy Infants: poor feeding, slow growth, and neurologic complications Toddlers: poor growth, progression of microcephaly, encephalopathy, megaloblastic anemia, developmental delays, and seizures Adolescents and adults: neurologic and psychiatric illness, cognitive decline, abnormal clot formation, spinal cord degeneration

Demirel C, Kilciksiz S, Evirgen-Ayhan S, et al

doi: 10.1016/j.celrep.2019.07.043