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doi: 10.1039/D4FO00987H 13 PeiLXieLWuJZhangHZhangX

556 Interestingly, the expression of SIRT1 in the spinal cord of WT mouse is reduced during normal aging, while the expression of SIRT1 in different regions of the brain (including the spinal cord, hippocampus, thalamus and cerebral cortex) in SOD1G93A mouse is increased

It modulates brain circuits involved in libido rather than directly altering gonadotropins

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Despite the pervasive role of miRNAs in essential biological processes and as promising therapeutic targets, there is only a few dedicated reviews on their role in regulation of the IGF-1 signaling pathway (Lee and Gorospe, 2010)