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The results were similar for a composite of the kidney-specific components of the primary outcome (hazard ratio, 0.79

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Regarding collateral effects, the most commonly reported were gastrointestinal-related (diarrhea, nausea, vomiting, constipation) mainly occurring during the dose escalation period

[18] In accordance with the above, MC 4 receptor agonists have garnered interest as potential treatments for obesity and insulin resistance, [19] [20] while MC 4 receptor antagonists have attracted interest as potential treatments for cachexia

Nevertheless, the classic antidepressants used in clinical practice today are not always effective for the different types of depression and suffer from problems such as low response rates and delayed effects [11]