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In vivo studies Animals The animal experiments were approved by the Animal Care and Use Committee of Peking University and were conducted in accordance with national and international guidelines

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Treatment should only be continued if there has been a beneficial metabolic response, defined as a reduction in HbA1c of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight

Ingredients: Creatine monohydrate, calcium carbonate, Niacin(nicotinamide), Pantothenic acid (calcium D-pantothenate), Vitamin B12 (cyanocobalamin),Thiamine (thiamin hydrochloride), Vitamin B6(pyridoxine hydrochloride), Riboflavin

Some patients benefit from a temporary dose increase to 2.7mg or 3.0mg weekly if tolerated