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However, intra-VTA Ex-4 did not change extinction following the reacquisition of alcohol self-administration or motivation for alcohol (Dixon et al., Nicotine Ex-4, at doses not affecting baseline locomotor activity, reduced nicotine-induced locomotor behavior, accumbal dopamine release, and blocked nicotine-induced CPP in mice

Life Sci (2002) 70(14):162130

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They can sting, itch, burn, and feel very dry