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The following sections examine representative systemsapelin, spexin, meteorin-like protein (METRNL), and oxyntomodulinwith explicit attention to the evidence supporting their metabolic roles, the reasons for historical underexploration, and the translational questions that remain unresolved

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Neurological and Dementia Preliminary evidence suggests potential benefits in autoimmune diseases with observed reductions in inflammation markers, but this is mainly based on observational data and requires more controlled trials for validation