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Many clinical trials show this pattern clearly: a steep initial drop, then a gradual flattening of the curve

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Most adverse events were mild to moderate gastrointestinal events, primarily occurring during the dose-escalation period

We thus assessed GRK2 recruitment to activated GLP-1R and its functional effects on -arrestin and G protein coupling using a nanoBRET-based assay in the rat pancreatic -cell line INS-1 832/3

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