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This imbalance is strongly linked to the breakdown of the mucosal barrier and high systemic LPS levels (Wang L

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J Immunol (2007) 178(7):4296303.10.4049/jimmunol.178.7.4296 39 SelleriSPalazzoMDeolaSWangEBalsariAMarincolaFMet alInduction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS

Some reviews note no apparent effect on pregnancy in sensitivity analyses, underscoring the gap between biologic plausibility and durable clinical benefit