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Glucuronidation (50-60%) - SAFE Primary detoxification pathway in adults Makes acetaminophen water-soluble for excretion INCREASES during pregnancy but cannot compensate for other pathway changes Severely underdeveloped in fetuses/newborns 2

Its thought to work by making more of the milk-producing hormone prolactin

Bjrnsson ES, Bergmann OM, Bjrnsson HK, Kvaran RB, Olafsson S

doi: 10.1161/HYPERTENSIONAHA.107.097386 12 AtefiN.BehrangiE.MozafarpoorS.SeirafianpourF.PeighambariS.GoodarziA

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