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A 2017 meta-analysis of randomised trials found significant reductions in fasting insulin and HOMA-IR with myo-inositol supplementation, alongside improvements in serum SHBG when taken for at least 24 weeks

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Semaglutide, in research terms Semaglutide is the most extensively studied of the three

Like other GLP-1 analogues, it acts on GLP-1 receptors to increase insulin secretion and decrease glucagon levels, leading to better blood sugar control and feelings of fullness