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Moreover, Sirt2 enhances macrophage activation in response to M.tb infection

Leukemia 15 , 16331640 (2001)

This is particularly relevant for combination strategies involving immunotherapy and metabolic pathway targeting, offering new avenues to overcome therapeutic resistance

Carcinogenesis In a 104-week carcinogenicity study in rats at dose levels of 2, 20, 60, or 80 mg/kg/day by oral gavage, the incidence of uterine stromal polyps was significantly increased in females at 80 mg/kg/day at systemic exposure 20 times the human exposure at 40 mg/day based on AUC

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