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The tyrosine modification in AOD-9604 improves peptide stability and may slightly enhance lipolytic activity

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AOD-9604 is the same fragment with an N-terminal tyrosine modification developed by Metabolic Pharmaceuticals to stabilize the molecule for clinical development

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Nanoparticle-based delivery systems (hyaluronic acid-functionalized KPV nanoparticles) have shown enhanced targeted delivery to inflamed colonic tissue, accelerating mucosal healing