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Users frequently report increased physical comfort and enhanced ability to engage in activities they previously found challenging due to excess weight or poor metabolic health

When a mouse eats a high-fat, high-calorie meal, its body will make more insulin but also more GLP-1, to guard against weight gain

Patients who receive melanocortin receptor pharmacotherapies should continue to limit ultraviolet radiation exposure and have regular dermatologic surveillance as part of standard, dermatologic health practice

Changes in body weight can alter how pressure is distributed across joints, how easily the body moves through space, and how comfortable routine activities feel over time

Questions remain on resolving cost, access and equity barriers and on whether to include those with diabetes in clinical trials