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What Happens After Stopping GLP-1s A study found that one year after stopping semaglutide (the active ingredient in Ozempic), patients regained two-thirds of their prior weight loss over the following 52 weeks

While studies and assessments of GLP-1 AOMs, such as the cost-effectiveness study by the Institute for Clinical and Economic Review (ICER), 24 emphasize the potential for improved outcomes in obesity-related chronic diseases (e.g., heart disease, diabetes, osteoarthritis) and the potential related savings, the cost of AOMs must be paid up front, often exceeding the political or financial capacity of state legislatures to fund the program adequately