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Cardiovascular risk reduction: As of October 2025, the 7 mg and 14 mg doses are FDA-approved to lower the risk of major adverse cardiovascular events such as heart attack or stroke in adults with type 2 diabetes who are at high cardiovascular risk

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Several of its authors have declared potential conflicts of interest, as outside of this study they are affiliated with companies that commercialize semaglutide drugs, such as Novo Nordisk, Sanofi, Eli Lilly, and AstraZeneca