glp-1 long-term use safety How safe are GLP-1s? Long-Term Effects Of GLP-1 Medications:

In addition to acting on neuronal cells, GLP-1R agonists also exert effects on microglia and astrocytes through cAMP/PKA signaling pathway

The lack of a detailed discussion on hydration, fundamental for the safety and efficacy of GLP-1 RA treatment, is a notable limitation considering existing research that the medications can suppress water intake [27]

Mol Biol Rep 38:25692572

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Obesity A recent meta-analysis, summarized studies focused on LC supplementation for a prolonged time (median 3 months) [40]