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To validate the effectiveness of A-RDN, protein levels of calcitonin gene-related peptide (CGRP), which is the dominant neurotransmitter for afferent renal nerves [37, 38], and tyrosine hydroxylase (TH), a marker for efferent sympathetic fibers in the renal pelvis were quantified
doi: 10.1111/dom.12291 44 HardieDG
Key Takeaways: PRP as a First-Line Injection for Knee Osteoarthritis Stronger and longer-lasting pain relief than HA and corticosteroid injections Reduces inflammation and promotes cartilage repair , rather than just masking symptoms Potential to slow OA progression , making it a disease-modifying therapy Fewer side effects compared to corticosteroids, which can accelerate cartilage loss with repeated use Given the growing body of high-level clinical evidence , PRP is increasingly being recommended as a first-line regenerative therapy for knee osteoarthritis, offering a biological approach to symptom management and disease modification
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