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To investigate the severe liver damage and increased mortality observed in hepsin / mice during the early stages after APAP administration, we employed ultra-performance liquid chromatography-tandem mass spectrometry to measure levels of APAP-cysteine adducts in mouse liver tissue, which indirectly assesses the generation of the toxic APAP metabolite, NAPQI (Hairin et al

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[DOI] [PMC free article] [PubMed] [Google Scholar] 177.Niu N, Mercado-Uribe I, Liu J