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For the first time in the history of obesity medications we see weight loss efficacy of a magnitude that might raise concern about excessive loss of lean body tissue due to the initial pronounced reduction in energy intake and subsequent risk of protein deficiency

rather, the cohorts included patients with an alcohol use disorder, schizophrenia, or bipolar disorder during benzodiazepine withdrawal [11]

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Rather, evidence for these alterations has been collected piecemeal, limiting the potential to inform our understanding of the interactions amongst relevant biochemical pathways