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It appears that it takes a considerable time (from 8 10 weeks) for dietary selenium supplementation to increase blood glutathione peroxidase (the enzyme that combines with Vitamin E to protect muscles & muscle activity)

doi:10.3390/molecules1 91119066

As a peptide derived from human gastric juice, it is natively resistant to low pH and proteolytic enzymes

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People with Digestive Issues : Individuals with digestive conditions such as Crohns disease, celiac disease, or irritable bowel syndrome (IBS) may have difficulty absorbing B12 from food