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MCAS is fundamentally a condition of inappropriate mast cell activation with little to no neoplastic proliferation, distinguished from mastocytosis

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In the skin, although all isoforms can be found, only FOXO1 is associated with epidermal morphogenesis and FOXO3 with melanin biosynthesis suggesting a non-redundant function in these cells while the role of FOXO4 and FOXO6 remains to be explored [75]

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47,48 For instance, the degree of HRV reduction, together with abnormal EEG microstate patterns, could help distinguish between ANS-dominant and central sensitization subtypes of NERD, thereby providing a rationale for individualized treatment