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These factors disrupt iron homeostasis by promoting hepcidin expression and inhibiting ferroportin-mediated iron export, thereby increasing intracellular free iron levels

Acyl-CoA synthetase long-chain family member 4, a key enzyme in phospholipid metabolism, facilitates the conversion of PUFAs, such as arachidonoyl and adrenic acid, into PUFA-CoA (25)

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The authors noted this is an off-label strategy and called for controlled trials to validate effectiveness and define who might benefit

Satyam SM, Bairy LK, Shetty P, Sainath P, Bharati S, Ahmed AZ, Singh VK, Ashwal AJ (2023) Metformin and dapagliflozin attenuate doxorubicin-induced acute cardiotoxicity in Wistar rats: an electrocardiographic, biochemical, and histopathological approach