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Semaglutide Subcutaneous semaglutide 2.4 mg once weekly is authorized for long-term weight control for adults and children over the age of 12 with obesity or overweight with at least one weight-related comorbidity [112]

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For controlled skin studies, topical application removes the confounders introduced by injection no injection site reactions, no systemic distribution diluting local concentration, no injection technique variability across research subjects