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Shared signaling pathways and targeted therapy by natural bioactive compounds for obesity and type 2 diabetes

Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome

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The dimerization process involves initial binding of magnesium to the aspartate in the starter sequence which inturn interacts with the pyrophosphate molecule of the thiamine diphosphate through hydrogen bonding [101], followed by one transketolase monomer engaging the pyrophosphate moiety and the other with the thiazolium and pyrimidine rings of ThDP [88, 97]