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Critical points are represented by the actual relevance of the mucus layer covering the epithelium of the nasopharynx, by the interaction of the meningococcus with the different cell types of the human nasopharynx and the local microbiota, and by the mechanism of invasion of the epithelium (intracellular or paracellular)

The transportation of Hh from posterior to anterior compartment requires Tout-velu (Ttv) 44, 45

By directly comparing the immune cells of healthy controls with those of ME/CFS and Long COVID patients, the study proved that severe oxidative stress is a shared, defining characteristic of both conditions

1 Arthroscopic procedures reveal the presence of chondral lesions in greater than 60% of patients, 2,3 and yearly incidence rates of chondral lesions nearly tripled between 1996 and 2011