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Cell-permeable 2-OG treatment partially phenocopied the effects of ML226, consistent with perturbed OGDHc and 2-OG accumulation stabilizing HIF-1 and decreasing 5hmC levels (Fig

Aging Cell 13, 699708

It also has potent antioxidant and anti-inflammatory effects, reducing oxidative stress in gingival and joint tissue

In its National Security Strategy and National Defense Strategy, released in December and January, respectively, the administration declared the Middle East largely resolved

This effect may be attributed to its modulation of molecular pathways involving matrix metalloproteinase (MMP)-2 and MMP-9 expression, as well as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 gene (NOX2) levels