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The Protein Crisis: Why Rapid Weight Loss Can Be Risky Tirzepatide (Mounjaro, Zepbound) is a powerful tool for weight reduction, but its effectiveness creates a unique nutritional challenge

Starting at 8 weeks of age, rats received tirzepatide (TZP, 25 nmol/kg, every two days), vehicle (VEH), or pair-fed vehicle (VEHPF) to control for differences in food intake for 4 weeks

Last reviewed: June 24, 2026 Last updated: June 24, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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Clinicians often recommend sipping fluids throughout the day, using oral rehydration solutions if vomiting occurs, and spacing larger fluid volumes at least 3060 minutes before or after meals