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With Wegovy, the expectation is progression unless side effects force a pause

What Happens Next

More recently, medications like semaglutide (Ozempic and Wegovy) or tirzepatide (Mounjaro or Zepbound) may result in significant weight loss

Compounded semaglutide typically comes in 5 mg/mL or 10 mg/mL concentrations

Alternatives might include switching to a different GLP-1 medication (some patients tolerate one better than another despite similar mechanisms), reducing the maintenance dose to a level that produces fewer GI effects while still providing benefit, or transitioning to tirzepatide or another agent in the class