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Finally, salinomycin (Sal)originally identified in a high-throughput screen for CSC-targeting agents (247, 248)sensitizes renal cancer to ferroptosis by downregulating PDIA4 via autophagy, thereby suppressing the ATF4SLC7A11GPX4 axis (249, 250)

Fast-aging XpdTTD/TTD mice treated with FOXO4-DRI showed restored fur density and improved coat condition a widely shared image that generated significant public interest (Baar et al., 2017)

P., Hugo, M

The redox imbalance could be targeted by chelate formation coupled Cu(II) reduction in the proliferating tissue

Another example is a study that reported Curcumin Encapsulated Lipidic Nanoconstructs (CLEN) achieving an approximately 1.4-million-fold increase in aqueous solubility and about a 70-fold improvement in oral bioavailability compared to free curcumin (40)