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Genomic Stratification for Precision Therapy Next-generation sequencing has enabled molecular subtyping of MPNSTs, identifying actionable mutations such as CDKN2A/B deletions, PRC2 inactivation, and TP53 mutations

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Everything else the review included, 35 of 36 studies, was done in animals, much of it by a single Croatian research group going back to the 1990s1

This is why these medications carry a black box warning for patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Abstract 1157: Identification of miRNAs that target the Epithelial-Mes enchymal Transition regulator, Zeb2, using transcriptome PCR arrays